AstraZeneca vaccine may give longer-lasting immunity

AstraZeneca vaccine may give longer-lasting immunity that is now helping to shield UK from latest Covid wave – but it’s still not approved in America

  • Pascal Soriot, chief executive at AstraZeneca, said restricting AZ jab in older people may European surge
  • Just 67million doses of AZ have been distributed across the continent compared to 440m doses of Pfizer
  • Britain’s neighbours are now starting to record higher intensive care rates despite having similar case rates
  • In the United States, three vaccines have been approved by the FDA: Pfizer-BioNTech, Moderna and Johnson & Johnson’s Janssen. The AstraZeneca vaccine has not been approved in America
  • 그만큼 AstraZeneca vaccine may give longer-lasting immunity that is now helping to shield the United Kingdom from Europe’s latest deadly wave of 코로나 19, but it is still not approved in the United States.

    Continental Europe is currently suffering a ferocious fourth wave of Covid hospital admissions that is not being seen across the English Channel, despite Britain having similar case numbers.

    Pascal Soriot, chief executive at AstraZeneca, said the decision by most major EU nations to restrict his company’s jab earlier in the yearand delay rolling the jab out to older peoplecould be behind the hospital figures.

    ‘When you look at the UK there was a big peak of infections but not so many hospitalisations relative to Europe,’ Mr Soriot told BBC Radio 4’s Today programme on Wednesday. ‘In the UK this vaccine was used to vaccinate older people whereas in Europe initially people thought the vaccine doesn’t work in older people.

    Just 67million doses of AZ have been distributed across the continent compared to 440m doses of the Pfizer-BioNTech jab, even though more recent studies suggest the Oxford-made vaccine provides longer protection against severe disease in older people.

    EU scepticism about the jab centred around the fact only two people over the age of 65 caught Covid in AZ’s global trials, 밖으로 660 participants in that age group. Sevel countries, including France, 독일, Belgium and Spain, restricted the use of the vaccine to the under-65s.

    Although the vaccine was eventually reapproved for elderly people in France, Germany and other major EU economies, the reputational damage drove up vaccine hesitancy and led to many elderly Europeans demanding they be vaccinated with Pfizer’s jab. 약간, such as Denmark and Norway, stopped using AZ altogether.

    화요일에, France saw its daily infections surpass 30,000 8 월 이후 처음으로 – 의 증가 63 percent in one week. In neighbouring Germany, the seven-day average of Covid deaths was twice that of the UK’s.

    수요일에, Germany reported 633 Covid-19 cases per million people, similar to the UK’s 627 cases per million people. 프랑스, meanwhile recorded just 98.61 cases per million.

    But in terms of ICU patientsan indicator of vaccine efficacyas of November 14 Germany reported 36 patients in intensive care per million people as a result of Covid-19. In France, that figure was almost 18. In the UK meanwhile, 있었다 14.35 Covid-19 patients in the ICU, with the number trending downwards.

    While Covid-19 cases are on the rise in Britain, with the country reporting 42,484 화요일에, deaths from the virus fell by 5.5 퍼센트 – and hospitalisations by 9.5 percent since last week.

    In the United States, three vaccines have been approved by the FDA: Pfizer-BioNTech, for those over the age of five; 현대, for over-18s; and Johnson & Johnson’s Janssen, also for over-18s. The AstraZeneca vaccine has not been approved by the public health body, which reiterated this fact as recently as November 2 안에 해제.

    Like Europe, the US is also seeing rising Covid cases going into winter. But unlike Europe, America has seen a drop in both the number of deaths per million people (currently almost half the rate than what was seen in September), and a similar drop off in number of ICU patients.

    The number of Covid intensive care patients in European countries like Belgium, 독일, the Netherlands and France are on the rise and heading into levels not seen since the start of the year. In comparison the UK's number of patients requiring intensive care is levelling off

    The number of Covid intensive care patients in European countries like Belgium, 독일, the Netherlands and France are on the rise and heading into levels not seen since the start of the year. In comparison the UK’s number of patients requiring intensive care is levelling off

    Just 67million doses of AZ have been distributed across the continent compared to 440m of Pfizer's, even though more recent studies suggest the UK jab provides longer protection against severe disease in older people

    Just 67million doses of AZ have been distributed across the continent compared to 440m of Pfizer’s, even though more recent studies suggest the UK jab provides longer protection against severe disease in older people

    Britain was seen as the 'sick man of Europe' in the summer after its Covid infection rate outpaced other nations. But as the continent heads into winter many other European nations have seen their case rates storm ahead. The UK is testing up to 10 times more than its EU neighbours, which inflates its infection rate

    Britain was seen as the ‘sick man of Europein the summer after its Covid infection rate outpaced other nations. But as the continent heads into winter many other European nations have seen their case rates storm ahead. The UK is testing up to 10 times more than its EU neighbours, which inflates its infection rate

    Studies have shown that AstraZeneca’s jab, which uses a more traditional vaccine technology, produces a greater T-Cell response in older people compared to the new MRNA vaccines produced by Pfizer and Moderna, which have been favoured in Europe.

    T-cells, which are more difficult to measure, are thought to provide longer lasting protection than antibodies which deliver an initial higher boost of protection but also see that defense fade faster over time. MRNA jabs are better at stimulating antibodies.

    Even if true, AstraZeneca’s role is likely only to be one of many contributing factors in Europe’s fresh wave. The UK frontloaded its infections earlier in the year by releasing all restrictions in July while the rest of the continent remained in some form of restrictions.

    Mobility data shows Europeans have also socialised more than Britons, whose behaviours have remained cautious even after lockdown. And EU countries have went with a three-week dosing gap between vaccines, compared to the UK’s 12 week space, which has since been shown to provide stronger and longer protection.

    그리고 앤드류 폴라드 교수는, chair of the Joint Committee for Vaccination and Immunisation (JCVI) — the independent body advising the British Government on jabbing policy — today said hospitalisations are now ‘largely restricted to unvaccinated people’, suggesting higher levels of admissions on the continent could be simply down to lower uptake of first and second doses.

    Mr Soriot added: ‘T-cells do matter…it matters to the durability of the response especially in older people, and this vaccine has been shown to stimulate T-cells to a higher degree in older people,’ 그는 말했다.

    ‘We haven’t seen many hospitalisations in the UK, a lot of infections for sure…but what matters is are you severely ill or not, are you hospitalised or not?’ 그는 덧붙였다. ‘And we haven’t seen so many of these hospitalisations in the UK.

    ‘The antibody response is what drives the immediate reaction or defence of the body when you’re attacked by the virus, and the T-cell response takes a little longer to come in, but it’s actually more durable – it lasts longer and the body remembers that longer.

    프랑스, 독일, 네덜란드, and Italy were among a slew of countries to restrict the Oxford-made vaccine for use in older people, claiming that there was not enough trial evidence to show that it was safe and effective. Some European countries later shunned the jab all together after small number of reports of deadly blood clots emerged.

    French President Emmanuel Macron was accused of politicising the roll out of the British-made vaccine in January when he trashed it as ‘quasi-effectivefor people over 65 and claimed the UK had rushed its approval, in what some described as bitterness over BrexitBritain’s decision to leave the EU bloc.

    Germany’s chancellor Angela Merkel, 66, also added to initial doubts over the vaccine, stating in February she would not get the jab as her country’s vaccine regulator infamously recommended at time that those over the age of 65 should not have the jab. But Merkel did eventually get the AstraZeneca in April.

    The scientific community had a mixed reaction to Mr Soriot’s comments today, largely agreeing with his comments on the AstraZeneca jab’s ability to generate a T-cell response but also highlighting that much more research needs to be done what that means in terms of its effectiveness.

    Dr Lance Turtle, an expert in infectious diseases University of Liverpool, said while AstraZeneca provided excellent protection from Covid it was far too early to determine if various vaccines were more or less effective.

    How ‘Freedom Daymay have saved Britain from Europe’s winter wave

    Throwing off Covid restrictions in the summer may have saved the UK from Europe’s winter wave, experts have claimed.

    On ‘Freedom Dayin July England dumped its remaining measures — including face masks and social distancing.

    This allowed the virus to let rip and cases soar over the warmer months when the NHS was less busy.

    Experts say the move frontloaded infections into the summer, bolstering immunity for the winter.

    Professor Paul Hunter, an infectious diseases expert at the University of East Anglia, said the UK was in a different position to Europe because it had so many infections earlier in the year.

    And Sir John Bell, an Oxford University professor and Government adviser, echoed his comments claiming that Freedom Day had ‘given us longer-term protection’.

    Sir John said he was confident that Christmas will be business as usual this year, telling Britons to ‘order that turkey, because it’ll be fine’.

    The UK was slammed as the ‘sick man of Europethroughout the summer and autumn for consistently recording the highest levels of infection on the continent.

    But many European neighbours including Austria, the Netherlands and Ireland are now recording a higher infection rate.

    Boris Johnson warned last week that Europe’s wave could still crash onto Britain’s shores.

    But he added there was nothing in the data at present to suggest England needed to move to Plan B — which would bring back face masks and work from home guidance.

    광고

    ‘현재, it is not possible to say for certain whether the AstraZeneca Covid vaccine is better than any other vaccine. Based on the real-world experience this is unlikely to be the case. If it is the case the difference will probably be small,’ 그는 말했다.

    Dr Turtle added that international comparisons regarding hospitalisations and infection rates for the virus are problematic.

    ‘There are many reasons why the infection rate, the hospitalisation rate and the death rate may vary between countries,’ 그는 말했다.

    ‘These include how many people have been vaccinated, and when they were vaccinated. The appearance of variants can have an effect, especially if they appear a long time after people have been vaccinated. The age of the population and the prevalence of other diseases will have an effect.

    ‘Drawing comparisons between countries presents many difficulties, and is very likely to lead to conclusions which are not reliable.

    Professor Matthew Snape, a vaccines expert, who was involved in the COMCOV study which Mr Soriot referenced in his comments today, highlighted how the situation was more complex than simply saying AstraZeneca prompted a greater T-cell response and more research needed to be done.

    ‘While a single dose of the AZ vaccine does induce a better T-cell response than the Pfizer MRNA vaccine, shortly after 2 doses the T-cell response was very similar. We are following up these studies to look at what these responses look like up to 6 months after the second dose,’ 그는 말했다.

    ‘Intriguingly, the best T-cell responses seem to come if you give a first dose of the AstraZeneca vaccine followed by Pfizer, and using vaccines across different platforms to optimise T-cell responses is an important avenue to explore to help generate the most effective vaccine responses.

    Professor Eleanor Riley, an expert in infectious diseases, said comparing vaccines and the role of antibodies or T-cells in Covid infection outcomes was complicated and any differences may be accounted for by human factors such as cost, distribution and availability.

    Dr Peter English, an expert in disease control, said Mr Soriot’s link between the UK’s relatively low hospitalisation and death rate and the greater use of the AstraZeneca vaccine and its relation to T-cell response was ‘plausiblebut added immunology is very complicated with many factors in play.

    Europe’s relationship with the British made AstraZeneca vaccine has been fraught, with accusations of states playing politics with the vaccine.

    Macron’s explosive comments questioning AstraZeneca’s effectiveness provoked outrage in January when he told an assembly of reporters: ‘Today we think that it is quasi-ineffective for people over 65.

    ‘What I can tell you officially today is that the early results we have are not encouraging for 60 to 65-year-old people concerning AstraZeneca.

    His comments came following a decision by Germany’s vaccine commission to restrict the use of the AstraZeneca jab in older people, stating it was only 6.5 per cent effective for the age group.

    European Commission president Ursula von der Leyen also waded into the issue, suggesting in February that the UK had got so far ahead in its vaccination programme by cutting corners on safety.

    The move and comments prompted concern from both British and European medics that some older people, who were particularly at risk from Covid infection, would be put off getting a potentially life-saving jab.

    Pascal Soriot, chief exec at AstraZeneca, suggested the decision by European states to restrict the jab earlier in the year could explain why they are now being hit hard by Covid

    Pascal Soriot, chief exec at AstraZeneca, suggested the decision by European states to restrict the jab earlier in the year could explain why they are now being hit hard by Covid

    From world’s non for profit Covid jab to outcast of the EU: AstraZeneca’s turbulent roll out

    30 12 월 2020: The AstraZeneca jab approved for emergency use in the UK

    29 일월: French President Emmanuel Macron claims the UK-made AstraZeneca vaccine is only ‘quasi-effectivein the over-65s just hours before the EU medicines regulator approves the jab

    26 이월: The 66-year-old German chancellor Angela Merkel comments she will not have the AstraZeneca jab as she is not in the recommended age group of under 65s

    1 행진: French Government U-turns, approving use of AstraZeneca for the over 65s

    11 행진: Denmark, Norway and Iceland suspend the use of AstraZeneca vaccines following concerns over blood clots

    15 행진: France suspends use of AstraZeneca over blood clot fears

    19 행진: France reapproves AstraZeneca but restricts it to over 55s

    7 4 월: The EU medicines regulator says it has found a rare blood clot side affect of the AstraZeneca jab but added that the overall risk/benefit remains positive in favour of the vaccine

    7 할 수있다: The UK restricts the use of the AstraZeneca vaccine to the over 40s over a small but statistically significant risk of blood clots in younger people.

    12 할 수있다: UK medicines regulator says it has spotted 294 cases of the clots in Britons given an first dose of AstraZeneca, affecting about one in 80,000

    9 구월: AstraZeneca and Pfizer jabs are approved in the UK to be used for third doses as part of a Covid booster programme

    4 십일월: The EU medicines regulator is reported to be in talks about approving the AstraZeneca vaccine for use as part of a booster programme

    광고

    And it was later revealed that this had come to pass, with thousands of people in France turning down the chance to get an AstraZeneca Covid jab following Macron’s comments and a wave of panic at the time regarding overhyped fears of blood clots caused by the vaccine.

    More research later found that younger people actually more likely to suffer the clotting issue, even though risk tiny at just one in 3.1 당 100,000 in people under 50-years-of-age.

    Actual deaths due to the issue are even rarer, one per 500,000 doses and far below the risk of developing blood clots from Covid itself.

    European leaders were later accused of having ‘blood on their handsfor promoting vaccine hesitancy over the AstraZeneca vaccine further abroad, and in countries with less robust healthcare systems world.

    The AstraZeneca jab was famously made not-for-profit with the intent of making the vaccine as accessible as possible for the world at a time when the pandemic had a death-grip on the planet.
    Some doses of the vaccine languishing in fridges in Europe were subsequently sent to countries like Namibia after some Europeans declined the jab, preferring vaccines made by the likes of Pfizer and Moderna.
    But this led to concerns by some Namibians that sub-par vaccines were being ‘dumpedon them and may have influenced vaccine uptake in the country.

    And on Malawi in May, 19,000 AstraZeneca doses were incinerated after going past their use-by date with a ‘lowuptake in the country.

    The war of words over vaccines in the early months of 2021 came amid an ongoing dispute over vaccine supplies in Europe, with some European states threatening to take shipments of vaccines destined for the UK for themselves.

    Originally the EU was eager to get the AstraZeneca jab, but the company struggled to meet the demand for the vaccine meaning shipments were delayed.

    Even today some European nations are still refusing to use AstraZeneca’s Covid vaccine with both Denmark and Norway suspended the jab over safety concerns in the first half of the year.

    The US has also not approved the AstraZeneca jab for use in the country.

    Some countries in Europe, notably Belgium, 독일, 네덜란드, and France are experiencing a rise in number of Covid intensive care patients, people who need the highest level of care due to the level of infection they have suffered from the virus.

    As of November 14, the date for which the latest data is available, Belgium recorded 44 intensive care patients with Covid per million people, Germany recorded 36 per million, 네덜란드 22 per million, and France 18 per million

    In comparison the number of patients requiring this level of care in the UK has levelled off in recent months, and as of November 18 look to be declining to just under 14 cases per million people.

    In terms of Covid cases the UK has recently been surpassed by many of its neighbours. Britain recorded about 605 new Covid cases per million people on November 21, far fewer than Belgium and The Netherlands which recorded about 1,188 과 1,227 cases per million people respectively.

    Cases in Germany have also rocketed up in the past few weeks, with the country recording about 586 cases per million people on November 21 and with no sign of slowing may exceed the UK’s cases in the coming days.

    While the differences in vaccine policy could be one of the reasons for the differences in Covid cases and hospitalisations between Europe and the UK there could be other factors at play. Vaccine uptake among the over-60s in Europe has varied.

    The UK's booster drive has steamed ahead of others on the continent. 이상 20 per cent of Brits have now got a booster, which is almost double the level in Austria and three times that in Germany

    The UK’s booster drive has steamed ahead of others on the continent. 이상 20 per cent of Brits have now got a booster, which is almost double the level in Austria and three times that in Germany

    While the average full vaccine uptake among older people across the continent is 86.5 퍼센트, individual nation states can differ hugely.

    Writing in the Guardian with Professor Brian Angus, a professor of infectious diseases at the University of Oxford, Sir Andrew said: ‘To the public, the pandemic was and still is a silent pestilence, made visible by the images of patients fighting for their next breath and reporters at intensive care units talking about the fear of patients and the exhaustion of doctors and nurses from behind their fogged visors.

    Which European countries are still refusing to roll out the AstraZeneca vaccine?

    Denmark

    The Danish health authority withdrew its approval for the AstraZeneca vaccine in April amid concerns over vanishingly rare blood clots.

    And seven-months later it is still not rolling out the jab.

    Health authorities said in June that the benefits of this vaccine still do not outweigh the risks.

    They added that most of the elderly population had already been inoculated and that, 당시, the epidemic there was largely under control.

    In late May the Danish Government asked health authorities to reconsider their suspension of the jab.

    노르웨이

    Norwegian health authorities suspended use of the AstraZeneca vaccine in March.

    And in May they dropped the jab from their roll out completely because of concerns over blood clots.

    Prime Minister Erna Solberg said at the time: ‘The Government has decided that the AstraZeneca vaccine will not be used in Norway, not even voluntarily.

    The Johnson and Johnson vaccine — which uses similar technology to AstraZeneca’s — has also been suspended in the country.

    광고

    ‘This ongoing horror, which is taking place in ICUs across Britain, is now largely restricted to unvaccinated people. 일반적으로, Covid is no longer a disease of the vaccinated; vaccines tend to limit this suffocating affliction, with a few exceptions.

    ‘In the short term, boosters and social restrictions will help prevent Covid from spreading among people who are unvaccinated this winter. But in the long run, the pressure of Covid on ICUs won’t be solved through these measures. The virus will eventually reach unvaccinated people. To prevent serious illness, these people need first and second doses of the vaccine as soon as possible.

    Vaccine uptake for the over 60s in Bulgaria and Romania is languishing at 32.9 과 40.7 per cent respectively while countries such as Iceland and Ireland have reported 100 per cent vaccine uptake.

    이에 비해, 이상 90 per cent of people over 60-years-of-age have had their second Covid vaccine with many now also having their booster jab.

    Some have also suggested that Europeans have been less cautious than Britons when it came to social mixing in the last few months with people returning pre-pandemic shopping levels and commuting patterns.

    Other analysts have suggested that the UK’s decision to reopen in July frontloaded our Covid cases to the summer whereas Britain’s European neighbours, who stayed in lockdown for longer, are now seeing this surge.

    On ‘Freedom Dayin July England dumped its remaining measures — including face masks and social distancing.

    This allowed the virus to let rip and cases soar over the warmer months when the NHS was less busy.

    The UK was slammed as the ‘sick man of Europethroughout the summer and autumn for consistently recording the highest levels of infection on the continent.

    But many European neighbours including Austria, the Netherlands and Ireland are now recording a higher infection rate.

    Boris Johnson also warned last week that Europe’s wave could still crash onto Britain’s shores.

    But he added there was nothing in the data at present to suggest England needed to move to its Plan B, which would see the reintroduction of some pandemic restrictions such as compulsory wearing of face masks and work from home guidance.

    Yesterday Austria became the first in Western Europe to impose a nationwide lockdown, with the Czech Republic and Slovakia have put the unvaccinated under stay-at-home orders.

    Elsewhere in Europe, Germany is also considering making vaccines compulsory and violent protests have erupted in the Netherlands, 벨기에, Switzerland over the weekend opposing curbs.

    German authorities have warned that everyone in the country will be either ‘vaccinated, cured or deadby the end of the winter.

    The above graph shows the proportion of people fully vaccinated against Covid, who have received two doses, in western Europe. It reveals that the UK has a similar jab uptake to many European nations

    The above graph shows the proportion of people fully vaccinated against Covid, who have received two doses, in western Europe. It reveals that the UK has a similar jab uptake to many European nations

    The above graph shows Covid hospital admissions per million people in Europe. It reveals that Belgium and the Netherlands are recording a rise, but that they remain flat in the UK. Austria is not included in this graph because no data was available

    The above graph shows Covid hospital admissions per million people in Europe. It reveals that Belgium and the Netherlands are recording a rise, but that they remain flat in the UK. Austria is not included in this graph because no data was available

    The above graph shows Covid deaths per million people from the virus. It reveals Austria and Belgium are starting to record surges. There is a lag between Covid cases and the reporting of any deaths due to the virus

    The above graph shows Covid deaths per million people from the virus. It reveals Austria and Belgium are starting to record surges. There is a lag between Covid cases and the reporting of any deaths due to the virus

    The the difference in fortunes between the UK and the continent could also partly be due to Britain’s booster drive. The UK has outpaced all its European neighbours in getting the new booster jabs to the most vulnerable groups.

    Yesterday over-40s are able to book their top up jab, which they can have from six months after their second dose. Uptake has surged above 70 per cent among the over-80s.

    Mr Soriot was speaking today as AstraZeneca opened a new state-of-the-art research and development facility, called The Discovery Centre, in Cambridge. The new £1billion building will accommodate 2,200 research scientists and focus on the creation of new medicines and therapeutic technologies.

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