UITSLUITEND: Close contacts of UK monkeypox cases given 'off-label' vaccine

UK bespeur nog TWEE apepokkegevalle: Gesondheidshoofde wat skarrel om die bron van uitbraak te vind, onthul dat nuwe pasiënte GEEN skakels met ander het nie – as they start vaccinating close contacts of all nine infected Brits to curb outbreak of rare tropical disease

  • Another two monkeypox cases have been detected in London and the South East
  • Brits are being offered a jab that in 2013 was approved in UK to prevent smallpox
  • Used ‘off-labelto prevent monkeypox after studies showed it is 85% effektief
  • ‘Ring vaccinationstrategy sees close contacts of cases targeted with vaccines
  • Another two monkeypox cases were detected in the UK today — with scientists still no closer to understanding what has sparked the mysterious outbreak.

    Health bosses confirmed the latest infected Britons, one of whom is in London while the other is in the South East, have no links to any other cases or travel to countries where the virus is endemic.

    Nine Britons have now been diagnosed with the tropical virus since the first patient was spotted on May 6. But experts fear dozens may have already caught it.

    Six cases, including the two confirmed today, are gay or bisexual men. Officials say the pattern of transmission is ‘highly suggestive of spread in sexual networks’.

    All but one of the patients — the first, wat vanaf Nigerië ingevlieg het - blykbaar in die VK besmet geraak het.

    Monkeypox has now also been spotted in Portugal and Spain.

    Dr Susan Hopkins, chief medical adviser, UK Health Security Agency, said the latest cases, coupled with infections reported across Europe, confirm concerns that there may be spread within the community.

    It comes as MailOnline today that revealed Britons who have been in close contact with apepokke cases are being given an ‘off-label’ entstof.

    They are being offered a jab that in 2013 was approved to prevent smallpox, which is part of the same family of viruses and is genetically very similar.

    There are no specific drugs or vaccines licensed for monkeypox in Britain, leaving doctors will limited options in preventing or treating it.

    Sewe Britte is met aappokke gediagnoseer en ses van hulle het dit blykbaar in die Verenigde Koninkryk opgedoen - in 'n teken dat die virus in die gemeenskap versprei. Die sewende Britse pasiënt het die virus uit Nigerië teruggebring, waar die siekte wydverspreid is. Minstens drie pasiënte ontvang sorg by spesialis-NHS-eenhede in Londen en Newcastle

    Britons who have been in close contact with monkeypox cases are being given an off-label vaccine known as Imvanex (lêer)

    Britons who have been in close contact with monkeypox cases are being given an off-label vaccine known as Imvanex (lêer)

    Monkeypokke kan tot een uit elke tien mense wat dit kry doodmaak, maar die nuwe gevalle het die Wes-Afrikaanse variant, wat dodelik is vir ongeveer een in 100.

    Aanvanklike simptome sluit koors in, [object Window], spierpyne, rugpyn, geswelde limfknope, koue rillings en uitputting.

    'n Uitslag kan ontwikkel, begin dikwels op die gesig, versprei dan na ander dele van die liggaam insluitend die geslagsdele.

    Die uitslag verander en gaan deur verskillende stadiums, en kan soos waterpokkies of sifilis lyk, voordat dit uiteindelik 'n skurfte vorm, wat later afval.

    Dr Hopkins gesê: ‘These latest cases, together with reports of cases in countries across Europe, confirms our initial concerns that there could be spread of monkeypox within our communities.

    ‘UKHSA has quickly identified cases so far and we continue to rapidly investigate the source of these infections and raise awareness among healthcare professionals.

    ‘We are particularly urging men who are gay and bisexual to be aware of any unusual rashes or lesions and to contact a sexual health service without delay if they have concerns. Please contact clinics ahead of your visit.

    ‘We are contacting any identified close contacts of the cases to provide health information and advice.

    It comes as MailOnline today revealed that close contacts of monkeypox cases were being offered the Imvanex vaccine ‘based on their risk factor’.

    Sources said the jab has been used in this way since 2018, toe 'n klein aantal gevalle met reisverbindings na Afrika opgespoor is.

    The strategy is being deployed again now that the virus appears to be spreading in the community for the first time.

    Studies have shown Imvanex — known as Jynneos in the US — is around 85 per cent effective at preventing a monkeypox infection.

    The US and EU have approved Imvanex specifically as a preventative for monkeypox, unlike the UK where it has only been green-lit for smallpox.

    It means in theory it is harder for medics in the UK to prescribe it to patients as it has to be used ‘off-labeland doctors can be held responsible for negative side effects.

    Professor Hunter said it would ‘probably be easier to get a hold of if it was approvedfor monkeypox, especially if cases rise and more doses are needed.

    Health bosses did not say how many people have been given the Imvanex jab.

    But studies during Covid suggest people have between three and 10 close contacts on average, meaning tens of Britons may already have received it.

    A spokesperson for the Medicines and Healthcare products Regulatory Agency (MHRA) aan MailOnline gesê: 'Daar is geen goedgekeurde entstof of medisyne vir apepokke in Groot-Brittanje nie.’

    Maar hulle het bygevoeg: “Ons hou die situasie noukeurig dop en werk saam met maatskappye om vinnig geskikte behandelings vir apepokke voor te stel.’

    But the vaccine itself can cause unpleasant side effects in certain people, including making eczema symptoms worse, according to Professor Paul Hunter, 'n kundige aansteeklike siektes aan die Universiteit van East Anglia.

    ‘So it is not something that we would give unless we had good reasons,’ hy het bygevoeg.

    Monkeypokke is 'n seldsame virusinfeksie wat ongewone uitslag of letsels veroorsaak (gewys in 'n uitdeelstuk wat deur die Sentrums vir Siektebeheer en -voorkoming verskaf word (CDC) in die VSA

    Apepokke is 'n seldsame virusinfeksie wat tot een uit elke tien van diegene wat besmet is doodmaak, maar nie maklik tussen mense versprei nie. Die tropiese siekte is endemies in dele van Afrika en is bekend vir sy seldsame en ongewone uitslag, stampe en letsels (lêerfoto)

    Verpleegsters en dokters word aangeraai om 'waaksaam' te bly vir pasiënte wat 'n nuwe uitslag of skurfte letsels het. (soos hierbo)

    Verpleegsters en dokters word aangeraai om 'waaksaam te bly'’ aan pasiënte wat 'n nuwe uitslag of skurfte letsels het (soos hierbo)

    Monkeypokke tref Europa: Five men in Portugal test positive as Spain probes eight suspected cases in men

    Monkeypokke has now been spotted in Portugal and Spanje, in what could be the first global outbreak of the rare disease.

    Spain is monitoring eight men who it believes are infected, with tests being carried out to confirm they have the virus.

    All of the men are gay or bisexual, volgens plaaslike media, and most were detected at STI clinics in Madrid.

    Five men in Portugal have also tested positive and at least 15 more cases are being investigated, health officials there said today.

    These cases are all male and mostly ‘young— but it is not yet clear how they caught the virus.

    Tot nou toe, apepokkegevalle was beperk tot reisigers en hul familielede wat van Wes- en Sentraal-Afrika teruggekeer het, waar die virus endemies is.

    But experts now fear it is spreading more widely for the first time, after seven Britons were diagnosed in the past fortnight.

    Six of them appear to have been infected in the UK and the majority are not linked, which suggests more cases are going undetected. Health chiefs are scrambling to find the source of the cases.

    Four of the British patients are gay or bisexual men, and officials say the pattern of transmission is ‘highly suggestive of spread in sexual networks’.

    Dr Simon Clarke, 'n mikrobioloog aan die Universiteit van Reading, het aan MailOnline gesê hy vermoed die Britse saaknommers is reeds 'in die tiene'.

    Maar hy het daarop aangedring dat die siekte nie soos Covid sal versprei nie, toevoeging: 'Ek sal verbaas wees as ons ooit by meer as uitkom 100 gevalle [in Brittanje]’.

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    Imvanex bevat 'n gemodifiseerde vorm van die vaccinia-virus, which is similar to the family of viruses that cause smallpox and monkeypox but does not cause disease in humans.

    As gevolg van sy ooreenkoms met die pokkevirusse, antibodies produced against this virus have cross protection.

    There are several other smallpox vaccines believed to be able to treat monkeypox, but they are less well researched.

    Doctors in the UK also have the power to use antiviral drugs for smallpox off-label to treat monkeypox.

    It comes after Portugal and Spanje announced they had detected cases of monkeypox, in what could be the first global outbreak of the disease.

    Spain is monitoring eight men who it believes are infected, with tests being carried out to confirm they have the virus.

    All of the men are gay or bisexual, volgens plaaslike media, and most were detected at STI clinics in Madrid.

    Five men in Portugal have also tested positive and at least 15 more cases are being investigated, health officials there said today.

    These cases are all male and mostly ‘young— but it is not yet clear how they caught the virus.

    Tot nou toe, apepokkegevalle was beperk tot reisigers en hul familielede wat van Wes- en Sentraal-Afrika teruggekeer het, waar die virus endemies is.

    But experts now fear it is spreading more widely for the first time.

    Dr Simon Clarke, 'n mikrobioloog aan die Universiteit van Reading, het aan MailOnline gesê hy vermoed die Britse saaknommers is reeds 'in die tiene'.

    Maar hy het daarop aangedring dat die siekte nie soos Covid sal versprei nie, toevoeging: 'Ek sal verbaas wees as ons ooit by meer as uitkom 100 gevalle [in Brittanje]’.

    Health experts investigating the new monkeypox outbreak in Britain say the virus can spread through sex.

    Tot nou toe, daar is nog nooit gevind dat dit seksueel oorgedra word nie.

    Maar dit was bekend dat dit deur noue kontak met liggaamsvloeistowwe oorgedra kan word, respiratoriese druppels en letsels - wat beteken dat dit teoreties moontlik was om deur seks oor te dra.

    Dr Mateo Prochazka, who leads the UKHSA team which is investigating monkeypox, described this route of transmission as ‘novel’.

    Nine people have been diagnosed with the virus in England over the past two weeks, six of which are in London.

    At least four are gay or bisexual men and only one has recent travel links to a country where the virus is endemic.

    Sexual health services are now working to identify more cases and control its spread.

    ALLES wat jy oor apepokke moet weet: Strain ‘transmits through sexand is about as deadly as the Wuhan Covid variant

    Monkeypokke appears to be spreading globally for the first time in an outbreak that has caught health officials off-guard.

    The UK has recorded seven cases of the virus but the majority of them are not linked which suggests more are going undetected.

    Spain and Portugal have also spotted the virus for the first time ever and the US is monitoring six people who were on a flight with a positive case.

    The majority of patients in the UK are gay or bisexual men, as are the eight Spanish men suspected of having the disease.

    Portuguese officials have confirmed five men tested positive and over a dozen more are thought to be infected.

    Health chiefs in the UK say the pattern of transmission is ‘highly suggestive of spread in sexual networks’.

    Until now monkeypox had only been detected in four countries outside of Africa — the UK, VSA, Israel en Singapoer, all of whom had links to Nigeria and Ghana.

    Infections are more common in central and western Africa, where they can result from direct contact with infected animals.

    Monkeypokke kan tot een in doodmaak 10 people it infects — but the strain spreading globally is milder and has a fatality rate of about one in 100.

    Dit is ongeveer dieselfde as die eerste Covid-stam wat uit Wuhan gekom het, entstowwe en natuurlike immuniteit het egter sedertdien die koronavirus baie swakker gemaak.

    Monkeypox’s similarity to smallpox means jabs and drugs against that virus are also effective.

    Hier is alles wat ons tot dusver oor die Britse apepokkie-uitbraak weet:

    Wat is apepokke?

    Apepokke is 'n seldsame virusinfeksie wat mense gewoonlik in die tropiese gebiede van Wes- en Sentraal-Afrika optel.

    Dit word gewoonlik versprei deur direkte kontak met diere soos eekhorings, wat bekend is om die virus te huisves.

    Egter, dit kan ook deur baie noue kontak met 'n besmette persoon oorgedra word.

    Apepokke is die eerste keer ontdek toe 'n uitbreking van 'n pokkeagtige siekte plaasgevind het by ape wat vir navorsing in 1958.

    Die eerste menslike geval is aangeteken in 1970 in die Demokratiese Republiek van die Kongo en die infeksie is sedertdien in 'n aantal Sentraal- en Wes-Afrika-lande aangemeld.

    Only a handful of cases have been reported outside of Africa and they were confined to people with travel links to the continent.

    Hoe dodelik is dit nie?

    Monkeypokke is gewoonlik lig, met die meeste pasiënte wat binne 'n paar weke sonder behandeling herstel. Tog, die siekte kan dodelik wees.

    Monkeypokke maak dood tot 10 persent van mense wat dit besmet.

    Egter, met ligter stamme is die sterftesyfer nader aan een in 100 - soortgelyk aan toe Covid die eerste keer getref het.

    Die Britse gevalle het almal die Wes-Afrikaanse stam van die virus gehad, wat sag is in vergelyking met die Sentraal-Afrikaanse stam.

    It is thought that cases in Portugal and Spain also have the milder version, though tests are underway.

    Is daar 'n kuur??

    Omdat apepokke nou verwant is aan die virus wat pokke veroorsaak, prikke vir pokke kan ook mense beskerm teen pokke.

    Een entstof, Jynneos, ook bekend as Imvamune of Imvanex, has been licensed in the US, maar dit is nie in die VK goedgekeur nie.

    Daar is getoon dat die entstof rond is 85 persent effektief in die voorkoming van aappokkies infeksie.

    Antivirale middels en saamgevoegde bloed van individue wat teen pokke ingeënt is, kan gebruik word om ernstige gevalle te behandel.

    Wat is die situasie met die huidige Britse uitbraak?

    Nine cases of monkeypox have been confirmed in the UK between May 6 en 18.

    Eight of the infected Brits had not recently travelled abroad, wat daarop dui dat daar vir die eerste keer oordrag tussen mense in die VK is.

    Daar word geglo dat sommige van die gevalle die virus deur seks opgedoen het - wat gesondheidskenners as 'bisar' beskryf het.

    Daar is nie gedink dat apepokke deur seksuele omgang versprei nie, maar deur noue kontak met letsels of respiratoriese druppels. Egter, net omdat dit tydens seks kan versprei, beteken dit nie dat dit die virus is nie’ primêre roete van oordrag, dit maak dit ook nie 'n SOI nie.

    Die NHS is besig om kontakte van diegene wat besmet is op te spoor om bykomende gevalle te identifiseer, aangesien dit nie duidelik is hoe al die besmette mense Monkeypox gevang het nie.

    Gesondheidsleiers werk ook saam met internasionale agentskappe om te bepaal of soortgelyke uitbrake elders voorkom.

    Wat weet ons tot dusver van die Britse sake?

    Six are based in London, two in the South East, en een in die Noordooste.

    Die eerste saak is in Mei bevestig 7 in 'n individu wat onlangs na Nigerië gereis het.

    Hulle het sorg ontvang by die deskundige aansteeklike siekte-eenheid by Guy's en St Thomas’ NHS Foundation Trust in Londen.

    Nog twee sake in Londen is in Mei aangekondig 14. Die besmette paar woon saam in dieselfde huishouding, maar was nie in kontak met die saak wat 'n week vroeër aangekondig is nie.

    Een van hierdie individue ontvang sorg by die deskundige aansteeklike siekte-eenheid by St Mary's-hospitaal in Londen. Die ander is by die huis isoleer en het nie hospitaalbehandeling nodig nie.

    Four more cases were announced on May 16, wat die VK-totaal op sewe te staan ​​bring.

    Two of the cases were in London, with the other two in the North East and South East of England.

    The four cases have no known connections with the earlier three cases, but two of them were known to each other. The four cases were in gay and bisexual men.

    Another two cases, one in London and one in the South East, were confirmed on May 18. Neither had recently travelled to a country where monkeypox is endemic. And neither case is linked with the previous seven.

    Mateo Prochazka, an STI expert and head of UKHSA team probing the outbreak, claimed the pattern of spread is ‘highly suggestive of spread in sexual networks’.

    Are there any cases in the US?

    There are no confirmed cases in the US, but officials are keeping tabs on six people who were in close contact with an infected person.

    The Americans were on the same flight as a British patient who travelled from Nigeria to the UK on May 4, and became the first case of the virus there.

    The potential US cases sat within a three-row radius of his seat, according to Jennifer McQuiston, a senior CDC official.

    She told STAT news they will be monitored for 21 dae.

    McQuiston also warned that Britain’s current spate of cases could be the tip of the iceberg.

    The lack of travel links and connections between the UK cases suggest there are ‘unknown chains of transmission happening’, sy het gese.

    ‘You have two clusters that have no link to travel or to other people who are known to be associated with a recognised outbreak.

    ‘It suggests that there are unknown chains of transmission happening. If there appears to be unknown chains of transmission, it just puts on alert to be thinking: ‘Could this be spreading outside the UK?”

    How worrying is it?

    UK health chiefs say the risk of a major outbreak is low.

    But they have urged gay, bisexual and other men who have sex with men to be extra vigilant because they appear to be at higher risk of catching it.

    These groups have been urged to look out for any unusual rashes or lesions on any part of their body, veral hul geslagsdele, and to contact a sexual health service without delay if they have concerns.

    Most scientists believe the outbreak will be small and transmission nothing like the levels seen with Covid.

    This is because monkeypox is poor at spreading between humans and relies on very close and prolonged contact between people.

    Hoe versprei dit?

    Apepokke is nie van nature 'n seksueel oordraagbare infeksie nie, alhoewel dit deur direkte kontak tydens seks oorgedra kan word.

    Aansteeklike letsels, waardeur infeksies die meeste waarskynlik oorgedra sal word, kan op enige deel van die liggaam verskyn.

    Die infeksie kan ook oorgedra word deur kontak met klere of linne wat deur 'n besmette persoon gebruik word.

    Tot nou toe, apepokke is nog net in vier lande buite Afrika opgespoor – die Verenigde Koninkryk, VSA, Israel en Singapoer.

    En al daardie sake het reisverbindings na Nigerië en Ghana gehad.

    Wat is die simptome??

    Aanvanklike simptome van aappokke sluit koors in, [object Window], spierpyne, rugpyn, geswelde limfknope, koue rillings en uitputting.

    Maar die mees ongewone kenmerk daarvan is 'n uitslag wat dikwels op die gesig begin, versprei dan na ander dele van die liggaam, commonly the hands and feet.

    Die uitslag verander en gaan deur verskillende stadiums voordat dit uiteindelik 'n skurfte vorm, wat later afval.

    Wat moet ek doen as ek simptome het?

    Enigiemand wat bekommerd is dat hulle met aappokke besmet kan word, word aangeraai om kontak met klinieke te maak voor hul besoek.

    Gesondheidshoofde sê hul oproep of bespreking sal sensitief en vertroulik hanteer word.