New Botswana variant with 32 'horrific' mutations

New Botswana variant with 32 ‘horrific’ mutations is the most evolved Covid strain EVER — as experts warn it could be ‘worse than Delta’

  • Only 10 cases of the strain — dubbed B.1.1.529 — have been spotted to date
  • Variant has 32 mutations, many of which suggest it is more vaccine resistant
  • Scientists warn the variant could be worse ‘than nearly anything else about’ 
  • British experts have sounded the alarm over a new Covid variant believed to have emerged in Botswana that is the most mutated version of the virus yet.

    Only 10 cases of the strain, which could be named ‘Nu’, have been detected so far but it has already been spotted in three countries, suggesting it is more widespread.

    It carries 32 mutations, many of which suggest it is highly transmissible and vaccine-resistant, and has more alterations to its spike protein than any other variant.

    Changes to the spike make it difficult for current jabs to fight off, because they train the immune system to recognise an older version of this part of the virus. 

    Dr Tom Peacock, a virologist at Imperial College who first picked up on its spread, described the variant’s combination of mutations as ‘horrific’.

    He warned that B.1.1.529, its scientific name, had the potential to be ‘worse than nearly anything else about’ — including the world-dominant Delta strain. 

    Scientists told MailOnline, however, that it might have too many mutations which could make it unstable and stop it becoming widespread globally.

    Three infections have been detected in Botswana and six in South Africa — where variant surveillance is more robust.

    One case has also been spotted in a 36-year-old in Hong Kong who recently returned from the continent. 

    There are no cases in Britain. But UK Health Security Agency, which took over from Public Health England, said it was monitoring the situation closely. 

    The mutant variant has sparked concern because of its ‘very extensive’ set of mutations. 

    Professor Francois Balloux, a geneticist at University College London, said it was likely the variant would be much more able to dodge antibodies than Delta.

    He told MailOnline: ‘For the time being, it should be closely monitored but there’s no need to be overly concerned, unless it starts going up in frequency.’

    He said its ‘burst’ of mutations suggests it may have emerged during a chronic infection in an immunocompromised person, such as an HIV/AIDS patient.

    Professor Lawrence Young, a virologist at Warwick Medical School, said it ‘looks like’ this mutant strain could be better at dodging vaccine-triggered immunity than other mutants based on its mutations.

    But he added: ‘It’s always difficult to say just by looking at [mutations], and so much depends on how the immune system sees the change and responds.

    ‘But it looks like just because of the severe load of [mutations] — some of which we know about quite a bit in terms of harming transmission — it looks like it might be slightly more qorrying than the South African variant.’

    He said it was hard to tell whether the virus would be more transmissible than Delta at this stage.

    Professor David Livermore, a microbiologist at the University of East Anglia, said the Botswana variant had sparked concern because of its ‘very extensive’ set of mutations. 

    He said: ‘This increases the risk of vaccine escape, but doesn’t prove that it will occur. 

    ‘Nor is the strain’s infectiousness clear, and it too will be affected by the spike’s structure.’

    The Botswana variant carries mutations K417N and E484A that are similar to those on the South African ‘Beta’ variant that made it better able to dodge vaccines.

    But it also has the N440K, found on Delta, and S477N, on the New York variant, which are also linked to antibody escape. 

    The variant also has mutations P681H and N679K on a specific part of its spike protein responsible for infection.

    And the mutation N501Y that makes viruses more transmissible and was previously seen on the Kent ‘Alpha’ variant and Beta among others.

    Other mutations it has include G446S, T478K, Q493K, G496S, Q498R and Y505H, although their significance is not yet clear.

    Dr Meera Chand, from the UKHSA, said: ‘The UK Health Security Agency, in partnership with scientific bodies across the globe, is constantly monitoring the status of SARS-CoV-2 variants as they emerge and develop worldwide. 

    ‘As it is in the nature of viruses to mutate often and at random, it is not unusual for small numbers of cases to arise featuring new sets of mutations. Any variants showing evidence of spread are rapidly assessed.’ 

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