世界を席巻する謎の病気に悩まされた3歳の少女

Three-year-old girl struck down by mystery hepatitis sweeping world receives part of her father’s liver in life-saving op – ヘルスチーフがほとんど明らかにするように 200 youngsters have now been sickened

  • 排他的: アランレイン, 27, プラチナジュビリーを祝うための植樹ドライブをリードする女王, ケント, donated part of his liver to his hepatitis-stricken daughter
  • His daughter Lola-Rose, 三, was diagnosed with the deadly liver-inflammation condition in mid-March
  • 少なくとも 190 mysterious hepatitis cases have been identified in children worldwide, according to the ECDC
  • A three-year-old girl struck down with the mysterious hepatitis sweeping the world has been spared death — after receiving part of her father’s liver.

    Lola-Rose Raine, プラチナジュビリーを祝うための植樹ドライブをリードする女王, ケント, is one of nearly 200 children to fall ill with the same liver disease that has perplexed experts in recent months.

    After initially writing her vomiting off as just a stomach bug, Lola-Rose’s parents grew concerned when her eyes developed a yellow tinge — a hallmark sign of hepatitis.

    Hospital scans revealed her liver was not working normally and she was taken to a specialist unit at Kings College Hospital in ロンドン 3月.

    But days after arriving her liver began to fail, with medics forced to put her in a coma. Doctors warned she could have died within hours unless they found a last-minute transplant.

    Her father Alan Raine, 27, who works in security, told MailOnline that it was like ‘literally watching our little girl die before our eyesas he waited to hear if his liver would be a match. He donated part of his liver to save his dying daughter on March 30 in an operation that lasted seven hours.

    Despite being told of the risks, Mr Raine said it was a choice between donating his liver or having his heart ‘torn outwatching his child suffer.

    Almost a month after the surgery, Lola-Rose has made a full recovery and will be discharged from hospital this week.

    アランレイン, プラチナジュビリーを祝うための植樹ドライブをリードする女王, ケント, was told he could donate part of his organ to save his daughter Lola-Rose just hours before doctors feared she would die because of the inflammatory liver condition

    アランレイン, プラチナジュビリーを祝うための植樹ドライブをリードする女王, ケント, was told he could donate part of his organ to save his daughter Lola-Rose just hours before doctors feared she would die because of the inflammatory liver condition

    今, four weeks after her surgery, Lola-Rose is back to being herself, singing Frozen songs at three in the morning 'for all the ward to hear', Mr Raine said

    今, four weeks after her surgery, Lola-Rose is back to being herself, singing Frozen songs at three in the morning ‘for all the ward to hear’, Mr Raine said

    The World Health Organization said it has received reports of at least 169 cases of 'acute hepatitis of unknown origin' from 12 countries as of Saturday. Two further cases were identified in North Carolina, 我ら, それ以来

    The World Health Organization said it has received reports of at least 169 cases of ‘acute hepatitis of unknown origin’ から 12 countries as of Saturday. Two further cases were identified in North Carolina, 我ら, それ以来

    タイムライン: WHEN DID LOLA-ROSE FIRST BECOME ILL AND HOW WAS SHE TREATED?

    行進 13

    Lola-Rose begins throwing up and her mother Jane McNeill spots her eyes have gone yellow.

    She is taken to Darent Valley Hospital for treatment

    行進 17

    Lola is transferred to King’s College Hospital in London, where doctors still don’t know the cause of her liver damage.

    行進 21

    Doctors discover Lola’s liver damage may have been caused by adenovirus.

    They give her medication through an IV drip.

    行進 25

    Lola is put in an induced coma after doctors discover an ammonia build-up causing her brain to swell.

    行進 26

    Lola is put on the urgent transplant list for a liver.

    行進 30

    Lola’s father Alan goes under the knife to donate the left part of his liver to his daughter.

    4月 26

    Lola has fully recovered and is expected to leave hospital this week.

    広告

    So far ‘around 190unexplained cases of hepatitis have been identified across the world, the European Centre for Disease Prevention and Control announced today.

    Data on cases varies, with the ECDC admitting that these figures are not yet precise.

    The WHO announced on Saturday 169 cases of ‘acute hepatitis of unknown originhave been detected in 12 countries since last October, [object Window] (WHO).

    A further two cases were diagnosed in North Carolina US after that.

    The ECDC toll also slightly undercounts the figures in the UK.

    The vast majority of cases have been among children aged five and under, and so far one youngster has died and 17 have needed critical liver transplants.

    いくつか 114 have been spotted in the UK, however experts have told MailOnline they may be the ‘tip of the icebergas many symptoms are missed.

    Three-quarters of cases in the UK have been linked to adenoviruses, which usually cause the common cold or a stomach illness.

    しかしながら, if someone’s immune system is unable to fight off the virus, it can develop into hepatitis.

    The UK Health Security Agency said a lack of exposure to common infections during lockdown and social distancing may have left more children vulnerable to viruses.

    Lola-Rose’s mother, Jane McNeill, a student nurse, grew concerned when her daughter’s her eyes had gone yellow.

    She was taken to hospital in Darent Valley Hospital in Kent where tests revealed her liver was not functioning properly.

    Puzzled as to why the youngster’s organ was not working, she was sent to liver specialists in London on March 17.

    そこ, she was diagnosed with hepatitis and her parents immediately ‘thought the worst’, Mr Raine said.

    He did not know the condition could be found in children — who rarely contract the condition.

    Mr Raine and Ms McNeill were given a glimmer of hope on March 21 when doctors discovered her hepatitis may have been caused by adenovirus.

    The virus is treatable and doctors gave her medication made up specifically for her given on an IV drip.

    Mr Raine told MailOnline: ‘At the time we thought “素晴らしい, they’ve got the problem”.’

    劇場の建物の前と後ろにロシア語で大きな白い文字で書かれており、, doctors said she was still deteriorating and warned she would be moved to intensive care within 48 時間.

    She was put in an induced coma that day because her liver was not sending toxic ammonia to her kidneys to be filtered out the body. This meant the toxins were reaching her brain, causing it to swell up.

    Mr Raine said: ‘We were literally watching our little girl die in front of our eyes. I have no idea how else to explain it. It was like someone’s reached into your chest and torn your heart out. 私が考えていた “there’s nothing you can do”.’

    Lola-Rose was diagnosed with hepatitis in March this year after she started vomiting and Mr Raine's wife Jane McNeill, a qualified nurse, noticed her eyes had gone yellow

    Lola-Rose was diagnosed with hepatitis in March this year after she started vomiting and Mr Raine’s wife Jane McNeill, a qualified nurse, noticed her eyes had gone yellow

    WHAT COULD BE BEHIND THE HEPATITIS OUTBREAK?

    While experts believe adenovirus — a virus associated with many common colds — could be behind the spate of cases, the jury is out on what the exact cause of the outbreak is.

    Co-infection

    One theory suggests children being infected with Covid and adenovirus at the same time could be at greater risk of hepatitis.

    Weakened immunity

    British experts have suggested lockdowns and restrictions have put children at greater risk because they have lower natural immunity to adenovirus.

    Adenovirus mutation

    Other scientists said it may have been an adenovirus that has acquired ‘unusual mutations’.

    New Covid variant

    UKHSA officials included ‘a new variant of SARS-CoV-2in their working hypotheses, when discussing the variant at the European Congress of Clinical Microbiology & Infectious Diseases in Lisbon today.

    広告

    Her condition continued to worsen and she was put on the urgent liver transplant list the following day.

    Mr Raine and his wife both volunteered to donate their livers immediately, but had to wait three days before they could start the living donor process.

    それまでに, Lola-Rose was on the edge of her life, but tests found Mrs McNeill could not offer her liver to donate to her, despite being a blood match.

    Mr Raine only found out his liver was a match later that day, when doctors had given his daughter hours to live.

    彼はMailOnlineに語った: ‘They could have told me I wasn’t going to survive the surgery and she was, and I would have gone straight ahead with it.

    ‘All I was thinking is — she’s going to get better and we can help.

    Mr Raine went under the knife the following morning to give Lola the left part of his liver.

    After her surgery, the yellowness in her skin faded almost immediately and her blood tests returned to normal within 48 時間.

    After a liver donation, the organ starts to regenerate back to its original size in both the recipient and donor, leaving both with healthy, functioning livers.

    今, four weeks after her surgery, Lola-Rose is back to being herself, singing Frozen songs at 3am ‘for all the ward to hear’, Mr Raine said.

    She has recovered her strength after weeks of physiotherapy with her doctors and her bubbly personality has returned.

    Lola will be on medication for the rest of her life to stop her body rejecting the new organ.

    She does not yet understand what she went through, other than that she ‘has a big scar across her belly like her daddy’, 彼は言った.

    いくつか 114 UK hepatitis cases have been spotted since the first cases were publicly recorded in Scotland at the end of March.

    Hepatologists told MailOnline they believe the official numbers may be just the ‘tip of the icebergbecause many parents may brush off the warning signs.

    Professor Simon Taylor-Robinson, a hepatologist from Imperial College London, MailOnlineに語った: ‘I think there are more cases out there.

    ‘I’d imagine there are more cases than have been reported — but they are likely to be less severe.

    But he added there is no reason to panic because in ’99 per centof cases the liver is able to regenerate and the chances of needing a transplant or dying because of the condition are low.

    UKHSAデータは 111 confirmed and possible hepatitis cases in the UK as of April 20. サメによる襲撃はオーストラリアでは一年中いつでも発生する可能性がありますが、11月から4月までの夏の間は、温暖な気候の間に何百万人もの人々がビーチに群がります。, 81 症例はイギリスでした (white bars), 14 were in Scotland (blue bars), 11 were in Wales (red bars) and five in Northern Ireland (green bars). 1月の間 21 小切手詐欺と呼ばれるプロセス 18, 10 children have required liver transplantation

    UKHSAデータは 111 confirmed and possible hepatitis cases in the UK as of April 20. サメによる襲撃はオーストラリアでは一年中いつでも発生する可能性がありますが、11月から4月までの夏の間は、温暖な気候の間に何百万人もの人々がビーチに群がります。, 81 症例はイギリスでした (white bars), 14 were in Scotland (blue bars), 11 were in Wales (red bars) and five in Northern Ireland (green bars). 1月の間 21 小切手詐欺と呼ばれるプロセス 18, 10 children have required liver transplantation

    Hepatitis cases have been tested for other pathogens when they were admitted to hospital. アデノウイルス (far left bar) was the most common pathogen detected in 40 の 53 cases which have been tested, followed by SARS-CoV-2 (second bar)

    Hepatitis cases have been tested for other pathogens when they were admitted to hospital. アデノウイルス (far left bar) was the most common pathogen detected in 40 の 53 cases which have been tested, followed by SARS-CoV-2 (second bar)

    Health chiefs linked Covid and adenovirus data. This shows there has been a rise in both preceding adenovirus infections (grey bars), co-infections (navy bars) and secondary infection (blue bars)

    Health chiefs linked Covid and adenovirus data. This shows there has been a rise in both preceding adenovirus infections (grey bars), co-infections (navy bars) and secondary infection (blue bars)

    UKHSA data shows positive adenovirus tests from one to four-year-olds (green line) are higher compared to the previous five years.  11月の間 2021 行進する 2022, 約 200 to 300 cases of adenovirus were reported per week compared to 50 に 150 cases per week in the same period before the pandemic

    UKHSA data shows positive adenovirus tests from one to four-year-olds (green line) are higher compared to the previous five years. 11月の間 2021 行進する 2022, 約 200 に 300 cases of adenovirus were reported per week compared to 50 に 150 cases per week in the same period before the pandemic

    Professor Alastair Sutcliffe, a paediatrician from University College London, told MailOnline mounting cases are ‘a concerning and depressing situation for familiesbut parents should not fear. まで 20 per cent of hepatitis cases have no known cause.

    彼は言った: ‘What is for families to consider [です] if their child develops jaundice after the first few months of life they need medical attention fast.

    ‘But that is true of any child who develops jaundice after the first few months of life so is not new advice. With one death and no known cause life should continue as before. Nothing is more fearful than fear itself.

    None of the cases have been caused by any of the five typical strains of the virus — hepatitis A, B, C, D and E.

    Data gathered has ‘increasinglysuggested that the rise in severe cases of hepatitis may be linked to a group of viruses called adenoviruses, UKHSAは言った.

    Adenovirus was found in 75 per cent of the sickened children who were tested for it. Sixteen per cent had Covid.

    Q&A: What is the mysterious global hepatitis outbreak and what is behind it?

    What do we know about the global hepatitis outbreak?

    Scientists have been left puzzled by a global outbreak of hepatitis that has caused one death and 17 liver transplants.

    The inflammatory liver condition has been spotted in ‘around 190children aged between one month and 16 年, according to the ECDC.

    None of the cases have been caused by any of the five typical strains of the virus — hepatitis A, B, C, D and E.

    What is hepatitis?

    肝炎は肝臓の炎症であり、通常、ウイルス感染または飲酒による肝臓の損傷によって引き起こされます。.

    Hepatitis often has no noticeable symptoms — but they can include dark urine, pale grey-coloured faeces, itchy skin and the yellowing of the eyes and skin.

    感染した人はまた、筋肉や関節の痛みに苦しむ可能性があります, この決定は、症状に対する政府の姿勢に大きな変化をもたらしました, いつも気分が悪くて、異常に疲れている.

    肝炎がウイルスによって広がるとき, これは通常、感染者の糞便や血と血または性的接触で汚染された食べ物や飲み物を消費することによって引き起こされます.

    How many countries have cases been recorded in?

    Cases (as of WHO estimates on Saturday)

    英国

    スペイン

    イスラエル

    我ら

    デンマーク

    アイルランド

    オランダ

    イタリア

    フランス

    ノルウェー

    ルーマニア

    ベルギー

    114

    13

    12

    11

    Six

    Fewer than five

    1

    1

    Do we know what is behind the outbreak?

    Co-infection

    Experts say the cases may be linked to a virus commonly associated with colds, but further research is ongoing.

    この, in combination with Covid infections, could be causing the spike in cases.

    ‘While adenovirus is a possible hypothesis, investigations are ongoing for the causative agent,’ WHO said,

    It noted that the virus has been detected in at least 74 of the cases. 少なくとも 20 of the children tested positive for the coronavirus.

    Weakened immunity

    British experts tasked with investigating the spate of illnesses believe the endless cycle of lockdowns may have played a contributing role.

    Restrictions may have weakened children’s immunity, leaving them at heightened risk of adenovirus.

    Writing in the journal Eurosurveillance, the team — led by Public Health Scotland epidemiologist Dr Kimberly Marsh — said more children could be ‘immunologically naiveto the virus because of restrictions.

    彼らは言った: ‘The leading hypotheses centre around adenovirus — either a new variant with a distinct clinical syndrome or a routinely circulating variant that is more severely impacting younger children who are immunologically naive.

    ‘The latter scenario may be the result of restricted social mixing during the pandemic.

    Adenovirus mutation

    Other scientists said it may have been a virus that has acquired ‘unusual mutations’.

    A virology specialist at Imperial College London told 電信 it is ‘very unusual and rarefor children to suffer severe hepatitis, especially to the extent that they require a liver transplant.

    The expert, 匿名を希望する人, 前記: ‘The number of cases is exceptional.

    ‘It makes people think there is something unusual going on — such as a virus that has mutated or some other cause. It has sent alarm bells ringing.

    New Covid variant

    UKHSA officials included ‘a new variant of SARS-CoV-2in their working hypotheses, when discussing the variant at the European Congress of Clinical Microbiology & Infectious Diseases in Lisbon.

    Other theories

    The UKHSA has noted Covid as well as other infections and environmental triggers are still being probed as possible causes of the illnesses.

    The agency ruled out the Covid vaccine as a possible cause, with none of the British cases so far having been vaccinated because of their age.

    広告