UK's Covid booster jabs ARE likely to protect against Omicron

Covid-versterker-stoot sal waarskynlik teen Omicron beskerm: Third dose of Pfizer and Moderna’s ‘massivelyboosts the body’s defences against virus by tripling T-cell levels, major study claims

  • Clinical trial results support the UK’s decision to use Pfizer or Moderna Covid vaccines as boosters
  • Six different manufacturer’s vaccines proved to be safe and effective as boosters, scientists said
  • They were jabs made by AstraZeneca, Pfizer, Modern, Novavax, Janssen and CureVac
  • Covid-versterker-entstowwe bied waarskynlik goeie beskerming teen die Omicron variant, kenners agter 'n groot nuwe studie sê - in die eerste sprankie hoop sedert die opkoms van die super-stam verlede week.

    Die liggaam se T-sel immuunrespons na 'n derde dosis dui daarop dat hulle sal voortgaan om te beskerm teen hospitalisasie en dood van die nuwe stam, volgens die staatsbefondsde verhoor.

    Dit ondersteun ook die VK se besluit om te gebruik Pfizer of Modern as boosters, met mRNA jabs wat die meeste teenliggaampies en T-selreaksies turbolaai.

    Daar word gemeen dat T-selle langer blywende en breër beskerming bied as teenliggaampies wat 'n aanvanklike hoër hupstoot van beskerming lewer, maar ook sien dat verdediging vinniger vervaag met verloop van tyd.

    Professor Saul Faust, proefleier en direkteur van die NIHR Kliniese Navorsingsfasiliteit by Universiteitshospitaal Southampton NHS Foundation Trust, gesê: 'Al verstaan ​​ons nie die verband daarvan met langtermyn-immuniteit behoorlik nie, die T-seldata wys vir ons dat dit blykbaar wyer teen al die variante stamme is, wat ons hoop gee dat 'n variante stam van die virus dalk hanteer kan word, beslis vir hospitalisasie en dood indien nie voorkoming van infeksie nie, deur die huidige entstowwe,’ Professor Faust gesê.

    Hy het gesê dat T-selreaksie nie net op die piekproteïen gefokus is nie, maar dat ''n baie wyer reeks antigene herken wat moontlik… gemeen aan al die variante.’

    Spesifiek oor Omicron gevra, hy het gesê: 'Ons hoop as wetenskaplikes is dat beskerming teen hospitalisasie en dood ongeskonde sal bly.’

    Monsters van die studie is nou aan die Britse gesondheidsveiligheidsagentskap oorgedra (UKHSA) om te kyk hoe goed die Omicron-variant deur entstowwe geneutraliseer kan word.

    The promising findings came as the former head of the UK’s Vaccines Taskforce said Omicron could pass in a fortnight and be a ‘storm in a teacup’.

    Clive Dix, who stood down from his role in April, bygevoeg: ‘If we look at all the facts that we know so far, none of them are heading in the direction of being a super concern.

    There is growing uncertainty about the Omicron variant, which is fuelling a meteoric rise in cases in South Africa, which first alerted the world about the highly-evolved virus on November 20.

    Nasionaal, gevalle daar gestyg tot 11,535 today marking a 370 persent styging in 'n week, en 'n derde op rondom 8,500 gister. Dit het die dominante stam in die land geword in bietjie meer as 'n week sedert dit amptelik ontdek is, opmaak 75 per cent of sequenced samples now after outpacing Delta at a ferocious pace.

    But public health experts in South Africa and the World Health Organization have insisted that cases are only mild and that vaccines should still be highly effective against the strain, despite a distinct lack of data.

    At a WHO press conference on Thursday, officials said that reports on the ground suggest the variant is much better at re-infecting people than Delta, which is why it’s spreading so fast in Guateng province where up to 80 per cent have natural immunity. In kontras met, only a quarter of South Africans are vaccinated against Covid.

    Yet despite the optimism, hospital admissions already appear to be on the rise in South African with today’s 274 op 180 per cent on last Thursday, even though they are rising from a low base.

    Covid-versterker-entstowwe sal waarskynlik goeie beskerming teen die Omicron-variant bied, kenners agter 'n regering-gefinansierde nuwe studie sê. Grafiek wys: Die aantal T-selle per 10^6 perifere bloed mononukleêre selle by mense wat twee dosisse van die AstraZeneca gehad het na 'n derde dosis van die Pfizer (rooi stawe) en Moderna (blou tralies) entstowwe

    Covid-versterker-entstowwe sal waarskynlik goeie beskerming teen die Omicron-variant bied, kenners agter 'n regering-gefinansierde nuwe studie sê. Grafiek wys: Die aantal T-selle per 10^6 perifere bloed mononukleêre selle by mense wat twee dosisse van die AstraZeneca gehad het na 'n derde dosis van die Pfizer (rooi stawe) en Moderna (blou tralies) entstowwe

    Boris Johnson received his coronavirus booster shot today as he said the nation is 'building ever higher the wall of protection' against the Omicron variant - but ministers are still unable to say when under-40s will be able to book

    Boris Johnson received his coronavirus booster shot today as he said the nation is ‘building ever higher the wall of protectionagainst the Omicron variantbut ministers are still unable to say when under-40s will be able to book

    Clive Dix, links, the former head of the Covid vaccines taskforce, said Omicron could pass in a fortnight and be just a 'storm in a teacup'

    Professor Saul Faust, who led the new study, said six different vaccines were safe and effective boosters

    Clive Dix, links, the former head of the Covid vaccines taskforce, said Omicron could pass in a fortnight and be just a ‘storm in a teacup’. Professor Saul Faust, who led the new study, said six different vaccines were safe and effective boosters

    There is growing uncertainty about the Omicron variant, which is fuelling a meteoric rise in cases in South Africa. Nasionaal, gevalle daar gestyg tot 11,535 today marking a 370 persent styging in 'n week, en 'n derde op rondom 8,500 gister

    There is growing uncertainty about the Omicron variant, which is fuelling a meteoric rise in cases in South Africa. Nasionaal, gevalle daar gestyg tot 11,535 today marking a 370 persent styging in 'n week, en 'n derde op rondom 8,500 gister

    Professor Saul Faust, who led the new study, said six different vaccines proved safe and effective as booster shots for people who had received two previous doses of AstraZeneca or Pfizer/BioNTech.

    These are AstraZeneca, Pfizer, Modern, Novavax, Janssen and CureVac. ‘All of the vaccines in our study do show a statistically significant boost… RNA (Pfizer and Moderna) very high, but very effective boosts from Novavax, Janssen and AstraZeneca as well,’ Professor Faust gesê.

    Boris Johnson gets his Covid booster

    Boris Johnson today received his coronavirus booster shot as he said the nation is ‘building ever higher the wall of protectionagainst the Omicron variantbut ministers are still unable to say when under-40s will be able to book.

    The Prime Minister, 57, said the ‘most important thing you can do under all circumstances is get your booster when you are eligibleas he urged people to get the jab when they are called forward to do so.

    He said 18.6million boosters have now been administered and insisted the doses are the UK’s best hope of fighting the new strain of the disease.

    Hy het gesê: ‘Whatever Omicron may or may not be able to do, it certainly will not negate the overall value of the boosters.

    His comments came after Science Minister George Freeman suffered a car crash TV interview this morning as he was unable to say when people in their 20s and 30s will be able to get their booster.

    Mr Johnson has pledged that all adults will be offered a third coronavirus vaccination by the end of January — but ministers have still not published a detailed rollout plan setting out when people under 40 can book.

    Mr Freeman was asked repeatedly why the Government is yet to publish the plan and when younger adults will be able to come forward.

    The minister could not give a firm answer and suggested people should ‘contact their GP now’ – despite health bosses telling the under-40s to wait to be called forward by the NHS.

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    Professor Faust, director of the NIHR Clinical Research Facility at University Hospital Southampton NHS Foundation Trust, said the vaccines worked well against existing variants.

    And he thinks T cell immunity — which was studied alongside antibodies in the research — could also play a significant role in fending off Omicron.

    The T cells work alongside antibodies in the immune system to seek out and destroy the virus.

    'Al verstaan ​​ons nie die verband daarvan met langtermyn-immuniteit behoorlik nie, die T-seldata wys vir ons dat dit blykbaar wyer teen al die variante stamme is, wat ons hoop gee dat 'n variante stam van die virus dalk hanteer kan word, beslis vir hospitalisasie en dood indien nie voorkoming van infeksie nie, deur die huidige entstowwe,’ Professor Faust gesê.

    He said T cell response was not just focused on the spike protein but ‘are recognising a much broader range of antigens that might… be common to all of the variants.

    Spesifiek oor Omicron gevra, hy het gesê: 'Ons hoop as wetenskaplikes is dat beskerming teen hospitalisasie en dood ongeskonde sal bly.’

    Samples from the government-backed CovBoost study have now been passed to the UK Health Security Agency (UKHSA) om te kyk hoe goed die Omicron-variant deur entstowwe geneutraliseer kan word.

    Jonathan Ball, professor of molecular virology at the University of Nottingham, said he is ‘convincedexisting jabs will continue to protect agains the new strain.

    Hy het gesê: ‘This is a fantastic study and it’s great to finally see the data that was no doubt pivotal in deciding the UK’s vaccine booster approach.

    ‘The data clearly shows that all boosters provided a lift to at least one aspect of your Covid immunity, and that side effects were, on the whole, mild.

    ‘The data also shows that an mRNA boostersuch as Moderna or Pfizerprovided the best overall boost, irrespective of whether your first doses were mRNA or (AstraZeneca).

    ‘The fact that the mRNA vaccine boosts gave a marked increase in both antibodies and T cells is great news, especially now, when our attention has been grabbed by the emergence of the Omicron variant.

    ‘We still don’t know how this increase in immunity translates into protection, especially against serious disease, but I am still convinced that our vaccines will continue to provide the protection that we need.The new trial, published in The Lancet, involved 2,878 people aged 30 or over receiving a booster 10 aan 12 weeks after their initial two-dose vaccination.

    ‘We still don’t know how this increase in immunity translates into protection, especially against serious disease, but I am still convinced that our vaccines will continue to provide the protection that we need.

    Algehele, daar was 13 different groups testing the boosters or acting as controls, with controls given a meningitis vaccine.

    Immunity was then assessed after 28 dae, with experts saying that more data will be published in the future on the immunity results three months and one year after receiving boosters.

    More data will also be published early next year looking at whether a longer period between second and third doses improves the response.

    All vaccines posed no safety concerns, volgens die studie, with fatigue, headache and sore arm the most commonly reported issues.

    VK se daaglikse Covid-gevalle spring 14% oor 'n week tot 53,945 maar sterftes val 4% met 141 meer slagoffers

    Britain’s Covid cases are continuing to climb with more than 53,000 recorded today, official Government data revealed amid fears about the Omicron variant.

    UK Health Security Agency (UKHSA) data shows there were 53,945 positive tests in the last 24 ure, op 14.2 persent op die 47,240 recorded last Thursday and the most since July 17.

    It was the second day in a row cases have increased week-on-week and only the second time in a week cases have breached the 50,000 mark.

    But the number of people dying with the virus fell to 141, af 4.1 persent op die 147 fatalities registered last week.

    And hospitalisations also fell, met 700 admissions recorded on Sunday, the latest date data is available for. It was down six per cent on the 745 seen the previous week.

    Intussen, separate data from a surveillance study today showed symptomatic Covid cases in the UK rose by nearly five per cent to more than 80,000 per day last week.

    The ZOE symptom-tracking study estimated that 80,483 people fell ill on any given day in the week ending November 27, based on test results from around 650,000 vrywilligers.

    It marked a rise of 4.9 per cent compared to the estimate on the previous week and means one in 61 Britons suffered a symptomatic infection at any given time, King’s College London scientists who run the study said.

    But infections started to fall in the over-55s, in a clear sign of the effect of booster vaccine doses — with more than 19million people now having had a third dose according to Government data.

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    Professor Faust gesê: ‘It’s really encouraging that a wide range of vaccines, using different technologies, show benefits as a third dose to either AstraZeneca or Pfizer/BioNTech.

    ‘That gives confidence and flexibility in developing booster programmes here in the UK and globally, with other factors like supply chain and logistics also in play.

    When looking at antibody levels in the trial, people who had received two doses of AstraZeneca initially had booster responses that were between 1.8 times higher to 32.3 times higher depending on the booster vaccine used.

    After two doses of Pfizer, the range was 1.3 times higher to 11.5 keer hoër, although they typically had a higher starting point.

    A seventh vaccine, made by Valneva, failed to have a significant booster effect in people given two initial doses of Pfizer.

    The government cancelled its contract with the firm in September, saying it would not secure approval from the UK medical regulator.

    The authors said the ratios should be interpreted with caution because they relate to immune response rather than real-world protection against disease.

    Mr Dix said if the new variant was more infectious than Delta but caused less severe symptoms, it might be sensible to relax restrictions in the long term to allow Omicron to become dominant.

    But he stressed the government was right to be cautious until more was known.

    Speaking to the i newspaper, he said he was ‘pretty calm and not really worriedabout the new variant.

    ‘I think everything will calm down soon, it won’t be a big story in a few weeks time.

    ‘If we look at all the facts that we know so far, none of them are heading in the direction of being a super concern.

    ‘Ja, it looks like it possibly transmits very easily, maybe even more easily than the Delta variant. But we’re not seeing serious disease yet and we’re not seeing death.

    ‘The picture looks like it’s now a milder virusand that’s what you expect with viruses.

    ‘They mutate to become more transmissable. They’re not looking to be deadly, because otherwise they don’t get transmitted.

    ‘This could even be a storm in a teacup. It could be that in two weeks time we’re back to just measuring the number of people with Delta and there’s less people in hospital and we may be at the tail of this.

    The promising results of the study came as the chair of the South African government’s committee on Covid vaccines said the ‘great majorityof Omicron infections in vaccinated people have been ‘mild’.

    Barry Schoub, aan Sky News gesê: ‘Beslis, op hierdie stadium, the news does look to be promisingthe great majority of the breakthrough infection is mild.

    ‘Our hospital surveillance is showing a little bit of an uptick but certainly nothing as dramatic as we’ve seen in the previous waves.

    ‘We’ve only had this virus around for just over a week so I think we really need to watch this space.

    Now Boris insists DON’T call off Christmas bookings after muddled government messaging sparks wave of festive cancellations

    Boris Johnson has now urged Britons not to call off their Christmas parties after his government’s muddled messaging sparked a wave of festive cancellations and a super-spreader event in Norway infected up to 60 people out of 120 with Omicron.

    The Prime Minister received his booster shot live on TV before telling Sky News there was no reason for Britons to change their plans.

    ‘People should follow the guidance we’ve set out,’ hy het gesê. ‘They shouldn’t be cancelling things, there is no need for that at all and it isn’t what we’re saying. The most important thing you can do in all circumstances is to have your booster when it becomes available.

    Earlier today Mr Johnson’s business minister plunged Christmas party plans for millions of Britons into further chaos after declaring it would be ‘sensibleto limit them to ‘four or five staffor axe them completely

    George Freeman, the Under Secretary of State for Science, also revealed that he was cancelling his own department’s bash, changing it to drinks on Zoom instead amid concerns over the new Omicron variant, erken: ‘It won’t be the best party in the world’.

    But hours later No 10 urged firms not to cancel Christmas parties and said people are free to kiss who they like after another minister advised against ‘snogging under the mistletoeover the holiday period.

    Mr Johnson’s latest intervention on Sky News will be seen as an attempt to bring clarity to his government’s position, after hospitality bosses complained muddled and confusing advice from ministers had led to a ‘catastrophic’ 48 hours for the industry.

    But there is growing uncertainty about the Omicron variant, which is fuelling a meteoric rise in cases in South Africa. Nasionaal, gevalle daar gestyg tot 11,535 today marking a 370 persent styging in 'n week, en 'n derde op rondom 8,500 gister.

    It has become the dominant strain in the country in just a week since it was officially discovered, opmaak 75 per cent of sequenced samples now after outpacing Delta at a ferocious pace.

    But public health experts in South Africa and the World Health Organization have insisted that cases are only mild and that vaccines should still be highly effective against the strain, despite a distinct lack of data.

    At a WHO press conference today, officials said that reports on the ground suggest the variant is much better at re-infecting people than Delta, which is why it’s spreading so fast in Guateng province where up to 80 per cent have natural immunity. In kontras met, only a quarter of South Africans are vaccinated against Covid.

    Yet despite the optimism, hospital admissions already appear to be on the rise in South African with today’s 274 op 180 per cent on last Thursday, even though they are rising from a low base.

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